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The Pathologist / Issues / 2026 / June / Virtual Staining and the Next Era of Pathology
Biochemistry and molecular biology Bioinformatics Digital and computational pathology Microscopy and imaging Precision medicine Technology and innovation Digital Pathology

Virtual Staining and the Next Era of Pathology

How AI enables scalable biomarker analysis that preserves tissue samples, addressing some of the most persistent bottlenecks in clinical care and research

By Kenneth To 06/19/2026 Learning 4 min read
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5 Topic Commentaries

Virtual Staining and the Next Era of Pathology

Virtual Staining and the Next Era of Pathology

  • Aydogan Ozcan
    Aydogan Ozcan, PhD

    Biophotonics and Computational Imaging

    •

    UCLA Samueli School of Engineering

    Instead of manually staining tissue during the course of the surgery, virtual staining can provide an answer much faster.

    Source
  • Yair Rivenson
    Yair Rivenson, PhD

    Computational Imaging

    •

    UCLA Samueli School of Engineering

    Virtual staining gives us capabilities that are nearly impossible to achieve today, such as simultaneously staining the same tissue sample with multiple types of stains for a more accurate diagnosis.

    Source
  • Adam de la Zerda
    Adam de la Zerda, PhD

    Biomedical Imaging (Structural Biology)

    •

    Stanford University School of Medicine

    We’ve not only created something that can replace the current gold-standard pathology slides for diagnosing many conditions, but we actually improved the resolution of these scans so much that we start to pick up information that would be extremely hard to see otherwise.

    Source
  • Kavita Sarin
    Kavita Sarin, MD, PhD

    Dermatology

    •

    Stanford University School of Medicine

    This has the potential to transform how we diagnose and monitor concerning skin lesions and diseases in the clinic.

    Source
  • X. Sunney Xie
    X. Sunney Xie, PhD

    Optical Imaging and Chemical Biology

    •

    Harvard University

    But this technique, we believe, is better because it’s live. Surgeons can now skip all the steps of taking a biopsy, freezing, and staining the tissue. This technique allows them to do it all in vivo.

    Source

This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.

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About the Author(s)

Kenneth To

Kenneth To is co-founder and CEO of ViewsML and a serial entrepreneur with more than 20 years of experience spanning medical affairs, commercialization, product and organizational strategy, and financing. He previously co-founded Wax-it Histology Services and has held leadership roles at STEMCELL Technologies and Eli Lilly and Company, where he led strategy, capability development, and key opinion leader engagement fortheir global medical affairs organization. He holds a PhD in Neuroscience from University of British Columbia and an MBA from Simon Fraser University.

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