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The Pathologist / Issues / 2026 / June / Virtual Staining and the Next Era of Pathology
Biochemistry and molecular biology Bioinformatics Digital and computational pathology Microscopy and imaging Precision medicine Technology and innovation Digital Pathology

Virtual Staining and the Next Era of Pathology

How AI enables scalable biomarker analysis that preserves tissue samples, addressing some of the most persistent bottlenecks in clinical care and research

By Kenneth To 06/19/2026 Learning 4 min read
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5 Key Takeaways
  • 1

    Pathology has evolved to include guiding ancillary testing and interpreting biomarkers, but workflows have not kept pace with modern medical demands.

  • 2

    Virtual staining enhances traditional pathology by providing faster, non-destructive biomarker analysis without replacing established techniques like immunohistochemistry.

  • 3

    AI has begun to impact pathology by predicting biomarker status from H&E images, but early models often lack spatial resolution of biomarker expression.

  • 4

    Virtual staining generates spatially resolved maps of biomarker expression at the individual cell level, improving interpretability and insight into tissue structure.

  • 5

    This approach allows for scalable biomarker analysis from a single H&E slide, reducing tissue consumption and turnaround times while enhancing patient triaging.

This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.

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About the Author(s)

Kenneth To

Kenneth To is co-founder and CEO of ViewsML and a serial entrepreneur with more than 20 years of experience spanning medical affairs, commercialization, product and organizational strategy, and financing. He previously co-founded Wax-it Histology Services and has held leadership roles at STEMCELL Technologies and Eli Lilly and Company, where he led strategy, capability development, and key opinion leader engagement fortheir global medical affairs organization. He holds a PhD in Neuroscience from University of British Columbia and an MBA from Simon Fraser University.

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