Clinical Scorecard: Gender-Diverse Diagnostic Guidance Issued

At a Glance

Key Highlights

• First comprehensive US guidance for laboratory services for gender-diverse patients.
• Recommends personalized diagnostic interpretation considering hormone status.
• Calls for standardized approaches in transfusion medicine for transgender and nonbinary individuals.
• Suggests incorporating organ inventories into electronic health records.
• Emphasizes the use of anatomically accurate, gender-neutral terminology in pathology.

Guideline-Based Recommendations

Diagnosis

• Use personalized approaches for interpreting laboratory test results.

Management

• Document both legal sex and affirmed gender identity in laboratory practices.

Monitoring & Follow-up

• Consider hormone exposure and clinical context in test result interpretation.

Risks

• Traditional reference intervals may lead to misinterpretation of results.

Patient & Prescribing Data

Adults who have received gender-affirming hormone therapy for at least six months.

Guidance provides a framework for adapting diagnostic workflows.

Clinical Best Practices

• Incorporate relevant anatomy and preventive screening decisions into laboratory findings.
• Standardize practices in transfusion medicine for gender-diverse donors and recipients.

Related Resources & Content

• ADLM Guidance Document