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1. Progerin present in 82 percent of CKD patients' arteries.

2. LMNA c.1824C>T mutation detected in 78 percent of CKD arteries.

3. Progerin frequency correlated with disease duration.

4. Increased endoplasmic reticulum stress in progerin-positive cells.

5. Findings suggest early vascular aging in CKD.

6. Higher ER stress and reduced VSMC density linked to progerin expression.

7. Mouse models showed similar findings to human tissue analysis.