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The Pathologist / Issues / 2014 / Nov / The Undisputable Value of Pharmacogenetic Testing
Oncology Oncology Genetics and epigenetics Precision medicine Profession Omics Professional Development

The Undisputable Value of Pharmacogenetic Testing

By Ron H. N. van Schaik 11/18/2014 1 min read
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5 Key Takeaways
  • 1

    Pharmacogenetic testing is increasing in requests and importance, prompting a task force to address its integration into clinical practice.

  • 2

    Barriers to pharmacogenetic testing include lack of access, missing clinical guidelines, and unclear reimbursement strategies.

  • 3

    Evidence supports the association between genetic variants and drug sensitivity, with significant findings for at least 60 different drugs.

  • 4

    Despite evidence, clinical community hesitates to adopt pharmacogenetic testing, as seen with CYP2D6 and CYP2C19 testing.

  • 5

    The task force aims to implement pharmacogenetics into patient care globally within two years by creating guidelines and networks.

This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.

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References

  1. C. Della Russo et al., “Novel Sensitive, Specific, and Rapid Pharmacogenomic Test for the Prediction of Abacavir Hypersensitivity Reaction: HLA-B*5701 Detection by Real-Time PCR”, Pharmacogen., 12, 567–576 (2011). V. O. Dezentje et al., “Clinical Implications of CYP2D6 Genotyping in Tamoxifen Treatment for Breast Cancer”, Clin. Cancer Res., 15, 15–21 (2009). M. A. Province et al., “CYP2D6 Genotype and Adjuvant Tamoxifen: Meta-Analysis of Heterogeneous Study Population”, Clin. Pharmacol. Therp., 95, 216–227 (2014). T. Simon et al., “Genetic Determinants of Response to Clopidogrel and Cardiovascular Events”, New Eng. J. Med., 360, 363–375 (2009). J. P. Collet et al., “Cytochrome P450 2C19 Polymorphism in Young Patients  Treated With Clopidogrel After Myocardial Infarction: A Cohort Study”, Lancet, 37, 309–317 (2009). www.pharmgkb.org

About the Author(s)

Ron H. N. van Schaik

Ron H. N. van Schaik is a professor of pharmacogenetics at Erasmus University Medical Center, Rotterdam, The Netherlands, and chair of the IFCC task force for pharmacogenetics.

More Articles by Ron H. N. van Schaik

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