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The Pathologist / Issues / 2025 / September / Prostate Cancer Screening Is Broken How Do We Fix It / Summary
Oncology Screening and monitoring Insights Regulation and standards

Prostate Cancer Screening Is Broken – How Do We Fix It?

Changing guidelines and flawed PSA thresholds have left men uncertain, but modern testing can restore confidence

By Jessica Allerton 09/26/2025 Discussion 6 min read
article Full Article Summary Notecard

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Prostate cancer affects 1 in 8 men, but current PSA screening methods face significant challenges leading to overdiagnosis and overtreatment. Jason Hafron of Michigan Institute of Urology discusses the limitations of PSA testing, highlighting the need for refined diagnostics such as IsoPSA and improved guidelines based on age and risk factors. Innovative approaches combining biomarkers and MRI could enhance decision-making for biopsies. As prostate cancer diagnostics evolve, a personalized risk assessment model integrating various data points is essential for effective screening.

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About the Author(s)

Jessica Allerton

Deputy Editor, The Pathologist

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