PSA testing can reduce mortality but has limitations.
Overdiagnosis is a major issue in PSA screening.
IsoPSA can significantly reduce unnecessary biopsies.
Age and family history affect PSA interpretation.
Guidelines recommend age-adjusted PSA thresholds.
MRI and biomarker tests improve risk assessment for biopsies.
Open discussions with patients about guidelines are essential.
Future diagnostics may integrate AI with multiple data sources.
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