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The Pathologist / Issues / 2025 / September / Prostate Cancer Screening Is Broken How Do We Fix It / Notecards
Oncology Screening and monitoring Insights Regulation and standards

Prostate Cancer Screening Is Broken – How Do We Fix It?

Changing guidelines and flawed PSA thresholds have left men uncertain, but modern testing can restore confidence

By Jessica Allerton 09/26/2025 Discussion 6 min read
article Full Article Summary Notecard

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  • PSA testing can reduce mortality but has limitations.

  • Overdiagnosis is a major issue in PSA screening.

  • IsoPSA can significantly reduce unnecessary biopsies.

  • Age and family history affect PSA interpretation.

  • Guidelines recommend age-adjusted PSA thresholds.

  • MRI and biomarker tests improve risk assessment for biopsies.

  • Open discussions with patients about guidelines are essential.

  • Future diagnostics may integrate AI with multiple data sources.

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About the Author(s)

Jessica Allerton

Deputy Editor, The Pathologist

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