Prostate Cancer Screening Is Broken – How Do We Fix It?

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• PSA testing can reduce mortality but has limitations.

• Overdiagnosis is a major issue in PSA screening.

• IsoPSA can significantly reduce unnecessary biopsies.

• Age and family history affect PSA interpretation.

• Guidelines recommend age-adjusted PSA thresholds.

• MRI and biomarker tests improve risk assessment for biopsies.

• Open discussions with patients about guidelines are essential.

• Future diagnostics may integrate AI with multiple data sources.