When Mitochondrial DNA Goes Rogue

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1. Imbalanced nucleotide metabolism leads to inflammation via mtDNA instability.

2. Ribonucleotides can be misincorporated into mtDNA, activating immune pathways.

3. MGME1-deficient mice show age-related renal inflammation connected to elevated ribonucleotides.

4. Cellular senescence is linked to increased ribonucleotide content in mtDNA.

5. Deoxyribonucleoside supplementation may mitigate inflammatory processes.

6. Study suggests further exploration on human tissues and clinical relevance.