A recent study, as published in the Annals of Diagnostic Pathology, revealed that p63 expression is observed in 80 percent of high-grade (G3) invasive breast carcinomas, while low-grade (G1) tumors showed no p63 expression. This research evaluated 60 biopsies classified by the Nottingham grading system and assessed p63 as a distinctive nuclear marker for myoepithelial cells in breast pathology. The study indicates that the presence of p63 in tumor cells correlates with higher histologic grades, warranting careful interpretation in cores where such positivity may misrepresent myoepithelial cells.
Newsletters
Receive the latest pathologist news, personalities, education, and career development – weekly to your inbox.
