A study published in Nature presents a comprehensive analysis of over 2.6 million cells derived from 30 tumor types across 12 organ systems, conducted by the Human Tumor Atlas Network (HTAN). Utilizing single-cell RNA sequencing and spatial transcriptomics, researchers identified four core malignant cell state behaviors: stress responses, proliferation, metabolic shifts, and invasive tendencies like epithelial-to-mesenchymal transition (EMT). The study highlights interactions within the tumor microenvironment and aims to improve tumor classification and immunotherapy strategies in pathology.
Newsletters
Receive the latest pathologist news, personalities, education, and career development – weekly to your inbox.