The UAE-based Arab Pangenome Reference (UPR) addresses gaps in genomic references for Arab populations.
Genomes of 53 individuals from eight Arab countries were analyzed.
The study generated 106 high-quality genome maps using advanced sequencing.
It uncovered 112 million undocumented DNA bases and 235,000 structural changes.
883 uniquely duplicated genes identified, some linked to recessive disorders.
mtUPR offers novel mitochondrial sequences and variations.
The UPR enhances accuracy in diagnostic variant detection.
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