Recent research at UC San Francisco highlights the role of cerebrospinal fluid (CSF) proteomics in enhancing the diagnosis of frontotemporal dementia (FTD), a significant but often overlooked cause of dementia in individuals under 60. Lead researcher Rowan Saloner emphasizes the necessity for reliable biomarkers, as current diagnostic methods are inadequate. The study discovered specific protein patterns in CSF that correlate with disease severity and could serve as early indicators of FTD, potentially guiding personalized treatment strategies and refining diagnostic tools.
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Caught in the Middle: Dementia in Midlife
Proteomic profiling of spinal fluid may provide the early diagnostic clarity of frontotemporal dementia in younger populations
08/11/2025
Interview
4 min read