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The Pathologist / Issues / 2025 / Aug / Caught in the Middle: Dementia in Midlife / Summary
Neurology Omics Neurology Biochemistry and molecular biology Liquid biopsy Molecular Pathology Insights Latest Profession

Caught in the Middle: Dementia in Midlife

Proteomic profiling of spinal fluid may provide the early diagnostic clarity of frontotemporal dementia in younger populations

08/11/2025 Interview 4 min read
article Full Article Summary Notecard

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Recent research at UC San Francisco highlights the role of cerebrospinal fluid (CSF) proteomics in enhancing the diagnosis of frontotemporal dementia (FTD), a significant but often overlooked cause of dementia in individuals under 60. Lead researcher Rowan Saloner emphasizes the necessity for reliable biomarkers, as current diagnostic methods are inadequate. The study discovered specific protein patterns in CSF that correlate with disease severity and could serve as early indicators of FTD, potentially guiding personalized treatment strategies and refining diagnostic tools.

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